[The activity of the neurohumoral regulatory systems, the status of the electrolyte balance and the clinical efficacy of Renitec in hypertension patients]. / Aktivnost' nekotorykh sistem neirogumoral'noi reguliatsii, sostoianie élektrolitnogo balansa i klinicheskaia éffektivnost' reniteka u bol'nykh gipertonicheskoi bolezn'iu.

Hypotensive effect of renitek (enalapril maleate) was assessed by activity of some neuroregulation systems and electrolyte balance in 16 patients with essential hypertension (EH). Maximal time of treatment for the assessment was 14 days. Renitek in a single dose 20-40 mg/day produced a response in 80% of EH stage II patients with low activity of plasma renin (PR). A hypotensive effect of the drug proved more essential in patients with higher baseline urinary excretion of aldosterone, adrenaline, noradrenaline and sodium. This effect is associated with stimulation of PR activity, urinary excretion of sodium, reduction in plasma and 24-h urine of aldosterone, adrenaline and noradrenaline concentrations. Renitek nonresponders exhibited high aldosterone concentration in plasma and its normal excretion with urine, diminished sodium excretion with urine. After 2 weeks of treatment blood and urine hormones were close to the initial levels while sodium excretion with urine went down.

[Clinico-neurohumoral interrelationships in neuroses]. / Kliniko-neirogumoral'nye vzaimootnosheniia pri nevrozakh.

The paper is related to studies of the sympathico-adrenal activity, hypophysisadrenal and entero-chromaphine systems in patients with hysterical and phobic neuroses. They detected certain regularities in the initial activities of these systems as well as of their reactivity depending upon the character of the functional symptom, psychological personality traits and cerebral dysfunctions.